Factors Explaining the Coincidence of Smoldering Multiple Myeloma and Primary Biliary Cholangitis: A Case Report

被引：1

作者：

El Dirani, Mirna ^{[1
]}

Nagaratnam, Julius M. ^{[2
]}

Kholoki, Samer ^{[3
]}

机构：

[1] St James Sch Med, Internal Med, Chicago, IL USA

[2] Avalon Univ, Internal Med, Sch Med, Chicago, IL USA

[3] La Grange Mem Hosp, Internal Med, Chicago, IL USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 07期

关键词：

autoimmune cirrhosis; autoimmune disease and cancer; multiple myeloma prognosis; smoldering multiple myeloma; primary biliary cirrhosis (pbc); AUTOIMMUNE HEPATITIS; CIRRHOSIS; OVERLAP;

D O I：

10.7759/cureus.26830

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To date, there have been nine reported instances of coinciding smoldering multiple myeloma (SMM) and primary biliary cholangitis (PBC). The term SMM was coined in 1980 to describe low-severity multiple myeloma cases, a hematologic neoplasia that involves the malignant proliferation of plasma cells. PBC is an autoimmune disorder targeting the intrahepatic bile ducts and is characterized by elevated anti-mitochondrial antibodies and often resulting in autoimmune liver cirrhosis. Currently, there is no plausible rationale for the coincidence of SMM and PBC in patients. This report investigates the relationship between SMM and PBC in a Hispanic 49-year-old female residing in the United States and attempts to determine the possible genetic and biochemical causes of this coincidence.

引用

页数：4

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