GRADE guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines

被引：92

作者：

Cuello-Garcia, Carlos A. ^{[1
,2
]}

Santesso, Nancy ^{[1
]}

Morgan, Rebecca L. ^{[1
]}

Verbeek, Jos ^{[3
]}

Thayer, Kris ^{[4
]}

Ansari, Mohammed T. ^{[5
]}

Meerpohl, Joerg ^{[6
,7
,8
]}

Schwingshackl, Lukas ^{[6
,7
]}

Katikireddi, Srinivasa Vittal ^{[9
]}

Brozek, Jan L. ^{[1
,10
]}

Reeves, Barnaby ^{[11
]}

Murad, Mohammad H. ^{[12
]}

Falavigna, Maicon ^{[13
]}

Mustafa, Reem ^{[1
,14
]}

Regidor, Deborah L. ^{[15
]}

Alexander, Paul Elias ^{[1
]}

Garner, Paul ^{[16
]}

Akl, Elie A. ^{[17
]}

Guyatt, Gordon ^{[1
,10
]}

Schunemann, Holger J. ^{[1
,10
]}

机构：

[1] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[2] Tecnol Monterrey Sch Med, Dept Hlth Qual Improvement, Monterrey, Nuevo Leon, Mexico

[3] Finnish Inst Occupat Hlth, Occupat Med, Cochrane Work Review Grp, Helsinki, Uusimaa, Finland

[4] US EPA, Integrated Risk Informat Syst IRIS Div, Natl Collar Environm Assessment, Washington, DC 20460 USA

[5] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[6] Univ Freiburg, Med Ctr, Inst Evidence Med, Freiburg, Baden Wurttembe, Germany

[7] Univ Freiburg, Fac Med, Freiburg, Baden Wurttembe, Germany

[8] Cochrane Germany Fdn, Cochrane Germany, Freiburg, Baden Wurttembe, Germany

[9] Univ Glasgow, MRC CSO Social & Publ Hlth Sci Unit, Greater Glasgow, Scotland

[10] McMaster Univ, Dept Med, Hamilton, ON, Canada

[11] Univ Bristol, Sch Clin Sci, Bristol, Avon, England

[12] Mayo Clin, Evidence Based Practice Ctr, Rochester, MN USA

[13] Univ Fed Rio Grande do Sul, Inst Hlth Technol Assessment, Porto Alegre, RS, Brazil

[14] Univ Kansas, Dept Med, Div Nephrol & Hypertens, Med Ctr, Kansas City, MO USA

[15] Kaiser Permanente, Evidence Serv, Care Management Inst, Oakland, CA USA

[16] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England

[17] Amer Univ Beirut, Dept Internal Med, Beirut Governorate, Lebanon

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 2022年 / 142卷

基金：

英国医学研究理事会;

关键词：

GRADE; Quality of evidence; Certainty of evidence; Risk of bias; Non-randomized studies; ROBINS; VITAMIN-D INTAKE; CONTROLLED-TRIALS; SYSTEMATIC REVIEWS; PREGNANCY;

D O I：

10.1016/j.jclinepi.2021.11.026

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background and Objective: This is the 24th in the ongoing series of articles describing the GRADE approach for assessing the certainty of a body of evidence in systematic reviews and health technology assessments and how to move from evidence to recommendations in guidelines. Methods: Guideline developers and authors of systematic reviews and other evidence syntheses use randomized controlled studies (RCTs) and non-randomized studies of interventions (NRSI) as sources of evidence for questions about health interventions. RCTs with low risk of bias are the most trustworthy source of evidence for estimating relative effects of interventions because of protection against confounding and other biases. However, in several instances, NRSI can still provide valuable information as complementary, sequential, or replacement evidence for RCTs. Results: In this article we offer guidance on the decision regarding when to search for and include either or both types of studies in systematic reviews to inform health recommendations. Conclusion: This work aims to help methodologists in review teams, technology assessors, guideline panelists, and anyone conducting evidence syntheses using GRADE. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license ( http:// creativecommons.org/ licenses/ by/ 4.0/ )

引用

页码：200 / 208

页数：9

共 28 条

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