The role of Pax genes in the development of tissues and organs:: Pax3 and Pax7 regulate muscle progenitor cell functions

被引：362

作者：

Buckingham, Margaret ^{[1
]}

Relaix, Frederic

机构：

[1] CNRS URA 2578, Inst Pasteur, Dept Dev Biol, F-75013 Paris, France

[2] INSERM, F-75013 Paris, France

[3] Univ Paris 06, F-75013 Paris, France

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2007年 / 23卷

关键词：

Pax1; Pax2; Pax4; Pax5; Pax6; Pax8; Pax9; myogenic regulatory factors Myf5 and MyoD; Six/Eya;

D O I：

10.1146/annurev.cellbio.23.090506.123438

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pax genes play key roles in the formation of tissues and organs during embryogenesis. Pax3 and Pax7 mark myogenic progenitor cells and regulate their behavior and their entry into the program of skeletal muscle differentiation. Recent results have underlined the importance of the Pax3/7 population of cells for skeletal muscle development and regeneration. We present our current understanding of different aspects of Pax3/7 function in myogenesis, focusing on the mouse model. This is compared with that of other Pax proteins in the emergence of tissue specific lineages and their differentiation as well as in cell survival, proliferation, and migration. Finally, we consider the molecular mechanisms that underlie the function of Pax transcription factors, including the cofactors and regulatory networks with which they interact.

引用

页码：645 / 673

页数：29

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