A bispecific antibody recognizing influenza A virus M2 protein redirects effector cells to inhibit virus replication in vitro

被引：12

作者：

FernandezSesma, A ^{[1
]}

Schulman, JL ^{[1
]}

Moran, TM ^{[1
]}

机构：

[1] MT SINAI MED CTR,DEPT MICROBIOL,NEW YORK,NY 10029

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

关键词：

D O I：

10.1128/JVI.70.7.4800-4804.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bispecific antibodies can be used to redirect cytotoxic T cells to kill virus-infected cells, overriding the need for major histocompatibility complex restriction, We produced a bispecific antibody (3F12) which binds influenza virus M2 protein and the T-cell receptor and can redirect staphylococcal enterotoxin B-activated T cells to kill influenza virus-infected cells and inhibit virus replication in vitro.

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收藏

页码：4800 / 4804

页数：5

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