Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

被引:178
作者
Jastrzebski, Katarzyna [2 ,3 ]
Hannan, Katherine M. [2 ]
Tchoubrieva, Elissaveta B. [2 ]
Hannan, Ross D. [2 ,3 ,4 ]
Pearson, Richard B. [1 ,2 ,3 ,4 ]
机构
[1] Peter MacCallum Canc Ctr, R Pearson Growth Control & Differentiat Lab, Melbourne, Vic 8006, Australia
[2] Peter MacCallum Canc Ctr, Trescowthick Res Labs, Growth Control & Differentiat Program, Melbourne, Vic, Australia
[3] Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia
[4] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3004, Australia
基金
英国医学研究理事会;
关键词
cell growth; protein synthesis; ribosome biogenesis; mTOR; ribosomal protein S6 kinase;
D O I
10.1080/08977190701779101
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Current understanding of the mechanisms by which cell growth is regulated lags significantly behind our knowledge of the complex processes controlling cell cycle progression. Recent studies suggest that the mammalian target of rapamycin (mTOR) pathway is a key regulator of cell growth via the regulation of protein synthesis. The key mTOR effectors of cell growth are eukaryotic initiation factor 4E-binding protein 1 (4EBP- 1) and the ribosomal protein S6 kinase (S6K). Here we will review the current models for mTOR dependent regulation of ribosome function and biogenesis as well as its role in coordinating growth factor and nutrient signaling to facilitate homeostasis of cell growth and proliferation. We will place particular emphasis on the role of S6K1 signaling and will highlight the points of cross talk with other key growth control pathways. Finally, we will discuss the impact of S6K signaling and the consequent feedback regulation of the PI3K/Akt pathway on disease processes including cancer.
引用
收藏
页码:209 / 226
页数:18
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