A new synthesis of 5-trifluoromethyluracil

被引：22

作者：

Andres, P

Marhold, A

机构：

[1] Central Research Department, Bayer AG

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1996年 / 77卷 / 01期

关键词：

synthesis; 5-trifluoromethyluracil; NMR spectroscopy; mass spectrometry;

D O I：

10.1016/0022-1139(95)03386-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

5-Trifluoromethyluracil, an important intermediate for the preparation of the antiviral trifluridine, is obtained by chlorinating thymine to give the new 2,4-dichloro-5-trichloromethylpyrimidine. Reacting the latter with hydrogen fluoride yields the new 2,4-difluoro-5-trifluoromethylpyrimidine, and hydrolysis with water gives 5-trifluoromethyluracil in high purity and good yield.

引用

页码：93 / 95

页数：3

共 21 条

[1]

ANDRES P, 1994, Patent No. 4222518

[2] TRIFLURIDINE - A REVIEW OF ITS ANTIVIRAL ACTIVITY AND THERAPEUTIC USE IN THE TOPICAL TREATMENT OF VIRAL EYE INFECTIONS [J].