Uterine Natural Killer Cells: Functional Distinctions and influence on Pregnancy in Humans and Mice

被引：170

作者：

Gaynor, Louise M. ^{[1
,2
]}

Colucci, Francesco ^{[1
,2
]}

机构：

[1] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England

[2] Univ Cambridge, Natl Inst Hlth Res, Dept Obstet & Gynaecol, Cambridge Biomed Res Ctr,Sch Med, Cambridge, England

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

基金：

英国惠康基金;

关键词：

uterine natural killer cells; uterine innate lymphoid cells; placenta; pregnancy; arterial remodeling; trophoblast; MHC CLASS-I; INNATE LYMPHOID-CELLS; METRIAL GLAND-CELLS; INTERFERON-GAMMA CONTRIBUTES; IMMUNOGLOBULIN-LIKE RECEPTOR; BLOOD NK CELLS; TROPHOBLAST CELLS; CUTTING EDGE; HLA-C; INHIBITORY RECEPTORS;

D O I：

10.3389/fimmu.2017.00467

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.

引用

页数：16

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