Uterine Natural Killer Cells: Functional Distinctions and influence on Pregnancy in Humans and Mice

被引：170
作者：
Gaynor, Louise M. [1 ,2 ]
Colucci, Francesco [1 ,2 ]
机构：
[1] Univ Cambridge, Ctr Trophoblast Res, Cambridge, England
[2] Univ Cambridge, Natl Inst Hlth Res, Dept Obstet & Gynaecol, Cambridge Biomed Res Ctr,Sch Med, Cambridge, England
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
基金：
英国惠康基金;
关键词：
uterine natural killer cells; uterine innate lymphoid cells; placenta; pregnancy; arterial remodeling; trophoblast; MHC CLASS-I; INNATE LYMPHOID-CELLS; METRIAL GLAND-CELLS; INTERFERON-GAMMA CONTRIBUTES; IMMUNOGLOBULIN-LIKE RECEPTOR; BLOOD NK CELLS; TROPHOBLAST CELLS; CUTTING EDGE; HLA-C; INHIBITORY RECEPTORS;
D O I：
10.3389/fimmu.2017.00467
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.
引用
收藏
页数：16
相关论文
共 220 条
[1]   Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta [J].
Adamson, SL ;
Lu, Y ;
Whiteley, KJ ;
Holmyard, D ;
Hemberger, M ;
Pfarrer, C ;
Cross, JC .
DEVELOPMENTAL BIOLOGY, 2002, 250 (02) :358-373
[2]   Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation [J].
Ain, R ;
Canham, LN ;
Soares, MJ .
DEVELOPMENTAL BIOLOGY, 2003, 260 (01) :176-190
[3]   Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases [J].
Anacker, Jelena ;
Segerer, Sabine E. ;
Hagemann, Carsten ;
Feix, Sonja ;
Kapp, Michaela ;
Bausch, Renate ;
Kaemmerer, Ulrike .
MOLECULAR HUMAN REPRODUCTION, 2011, 17 (10) :637-652
[4]   Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells [J].
Andrews, Daniel M. ;
Sullivan, Lucy C. ;
Baschuk, Nikola ;
Chan, Christopher J. ;
Berry, Richard ;
Cotterell, Claire L. ;
Lin, Jie ;
Halse, Heloise ;
Watt, Sally V. ;
Poursine-Laurent, Jennifer ;
Wang, Chyung-Ru ;
Scalzo, Anthony A. ;
Yokoyama, Wayne M. ;
Rossjohn, Jamie ;
Brooks, Andrew G. ;
Smyth, Mark J. .
NATURE IMMUNOLOGY, 2012, 13 (12) :1171-+
[5]   Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48 [J].
Apps, Richard ;
Gardner, Lucy ;
Traherne, James ;
Male, Victoria ;
Moffett, Ashley .
HUMAN REPRODUCTION, 2008, 23 (11) :2535-2548
[6]   A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1 [J].
Apps, Richard ;
Gardner, Lucy ;
Sharkey, Andrew M. ;
Holmes, Nick ;
Moffett, Ashley .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (07) :1924-1937
[7]   Ex vivo functional responses to HLA-G differ between blood and decidual NK cells [J].
Apps, Richard ;
Sharkey, Andrew ;
Gardner, Lucy ;
Male, Victoria ;
Kennedy, Pippa ;
Masters, Leanne ;
Farrell, Lydia ;
Jones, Des ;
Thomas, Rasmi ;
Moffett, Ashley .
MOLECULAR HUMAN REPRODUCTION, 2011, 17 (09) :577-586
[8]   Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies [J].
Apps, Richard ;
Murphy, Shawn P. ;
Fernando, Raymond ;
Gardner, Lucy ;
Ahad, Tashmeeta ;
Moffett, Ashley .
IMMUNOLOGY, 2009, 127 (01) :26-39
[9]   Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors [J].
Arase, H ;
Mocarski, ES ;
Campbell, AE ;
Hill, AB ;
Lanier, LL .
SCIENCE, 2002, 296 (5571) :1323-1326
[10]   Cutting edge:: The mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (α2 integrin, very late antigen-2) [J].
Arase, H ;
Saito, T ;
Phillips, JH ;
Lanier, LL .
JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1141-1144
12345678910