Wnt/Ca2+ signaling pathway: a brief overview

被引：429

作者：

De, Antara ^{[1
]}

机构：

[1] Saha Inst Nucl Phys, Crystallog & Mol Biol Div, Kolkata 700064, India

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2011年 / 43卷 / 10期

关键词：

Wnt5a; calcium signaling; development; cancer; inflammation; neurodegeneration; PROTEIN-KINASE-C; NERVE GROWTH CONES; BETA-CATENIN; WNT/BETA-CATENIN; AXON GUIDANCE; EPIGENETIC REGULATION; HIPPOCAMPAL-NEURONS; ALZHEIMERS-DISEASE; PANCREATIC-CANCER; FRIZZLED HOMOLOGS;

D O I：

10.1093/abbs/gmr079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The non-canonical Wnt/Ca2+ signaling cascade is less characterized than their canonical counterpart, the Wnt/beta-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca2+ signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca2+ pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca2+ signaling pathway.

引用

页码：745 / 756

页数：12

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