Highly Efficient and Modularly Tuned Bicyclic Organocatalyst for the Enantioselective Michael Addition of Aldehydes to Nitroalkenes

被引：5

作者：

Xiao, Jian ^{[1
,2
]}

Xu, Feng-Xia ^{[1
]}

Lu, Yun-Peng ^{[1
]}

Liu, Yan-Ling ^{[1
]}

Loh, Teck-Peng ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2011年 / 12期

关键词：

organocatalyst; bicyclic; enamine control; Michael addition; BOND-FORMING REACTIONS; 2,3-DISUBSTITUTED 4-NITROKETONES; ASYMMETRIC AMINOCATALYSIS; ALDOL REACTIONS; SILYL ETHERS; KETONES; ACTIVATION; CATALYSIS; FUNCTIONALIZATION; WATER;

D O I：

10.1055/s-0030-1260527

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new type of bicyclic organocatalyst has been successfully applied to the asymmetric Michael addition of aldehydes to nitrostyrenes in good yields and good enantioselectivities by using a self-assembly strategy. The success of this reaction is attributed to good control of the geometry of the enamine and efficient face shielding.

引用

页码：1912 / 1917

页数：6

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