Behavioural response of cells and bacteria on single and multiple doped Sr and Ag S53P4 sol-gel bioglass

被引：21

作者：

Swe, Thet Thet ^{[1
,3
]}

Shariff, Khairul Anuar ^{[1
]}

Mohamad, Hasmaliza ^{[1
]}

Ishikawa, Kunio ^{[2
]}

Hayashi, Koichiro ^{[2
]}

Abu Bakar, Mohamad Hafizi ^{[4
]}

机构：

[1] Univ Sains Malaysia, Sch Mat & Mineral Resources Engn, Nibong Tebal 14300, Penang, Malaysia

[2] Kyushu Univ, Fac Dent Sci, Dept Biomat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[3] Univ Yangon, Dept Phys, Kamayut 11041, Yangon, Myanmar

[4] Univ Sains Malaysia, Sch Ind Technol, Bioproc Technol Div, George Town 11800, Penang, Malaysia

来源：

CERAMICS INTERNATIONAL | 2020年 / 46卷 / 11期

关键词：

Antibacterial; Bioceramic; Bioglass; Bone remodelling; Sol-gel method; BIOACTIVE GLASS; SILVER NANOPARTICLES; ANTIBACTERIAL; SILICATE; CYTOTOXICITY; SUBSTITUTION; SCAFFOLDS; STRONTIUM; 45S5;

D O I：

10.1016/j.ceramint.2020.04.094

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The aim of this study is to investigate the response of cells and bacteria on Sr, Ag, and Sr + Ag doped S53P4 sol-gel bioglass. In this study, 3 mol% of SrO and 1 mol% of Ag2O were selected as doping for single and multiple doped S53P4 sol-gel bioglass. These doped specimens were denoted as BG, BG-3S, BG-1A, and BG-3S1A throughout the study. Cell study showed that the BG-3S1A specimen exhibited the highest proliferation of MC3T3-E1 osteoblast-like cells, ALP activity, and bone nodule formation in comparison with other specimens. Meanwhile, antibacterial study of the BG-3S1A specimen showed relatively similar antibacterial responses towards Escherichia coli and Staphylococcus aureus in comparison with the BG-1A specimen. Therefore, these findings proved that by combining appropriate amount of Sr and Ag doping ions into S53P4 bioglass composition, cellular proliferation and antibacterial response could be stimulated, which could benefit patients who suffer from bacteria-infected bone defect diseases.

引用

页码：17881 / 17890

页数：10

共 46 条

[1]

[Anonymous], IMPL SURG IN VITR EV

[2]

[Anonymous], BIOMEDICAL GLASSES

[3]

[Anonymous], BIOMED RES INT

[4]

[Anonymous], SYNTHESIS CHARACTERI

[5]

[Anonymous], AIP C P

[6] An in vitro biological and anti-bacterial study on a sol-gel derived silver-incorporated bioglass system [J].

Balamurugan, A. ;

Balossier, G. ;

Laurent-Maquin, D. ;

Pina, S. ;

Rebelo, A. H. S. ;

Faure, J. ;

Ferreira, J. M. F. .

DENTAL MATERIALS, 2008, 24 (10) :1343-1351

[7] Effects of silicate and carbonate substitution on the properties of hydroxyapatite prepared by aqueous co-precipitation method [J].

Bang, L. T. ;

Ramesh, S. ;

Purbolaksono, J. ;

Ching, Y. C. ;

Long, B. D. ;

Chandran, Hari ;

Ramesh, S. ;

Othman, R. .

MATERIALS & DESIGN, 2015, 87 :788-796

[8] A new sol-gel process for producing Na2O-containing bioactive glass ceramics [J].

Chen, Qi-Zhi ;

Li, Yuan ;

Jin, Li-Yu ;

Quinn, Julian M. W. ;

Komesaroff, Paul A. .

ACTA BIOMATERIALIA, 2010, 6 (10) :4143-4153

[9] 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering [J].

Chen, QZZ ;

Thompson, ID ;

Boccaccini, AR .

BIOMATERIALS, 2006, 27 (11) :2414-2425

[10]

Coyle M.B., 2005, Manual of Antimicrobial Susceptibility Testing

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