Recent trends in orexin research-2010 to 2015

被引：72
作者：
Boss, Christoph [1 ]
Roch, Catherine [2 ]
机构：
[1] Actel Pharmaceut Ltd, Drug Discovery Chem, CH-4123 Allschwil, Switzerland
[2] Actel Pharmaceut Ltd, Drug Discovery Pharmacol, CH-4123 Allschwil, Switzerland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 15期
关键词：
Orexin; G-protein-coupled receptors; Sleep disorders; Anxiety; Addiction; Hypothalamus; RECEPTOR ANTAGONIST 2-SORA; SLEEP; DISCOVERY; POTENT; TETRAHYDROISOQUINOLINES; HYPOTHALAMUS; HYPOCRETINS; ACT-462206; EXPRESSION; NARCOLEPSY;
D O I：
10.1016/j.bmcl.2015.05.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A and orexin-B). The orexin-peptides are transported to areas of the brain regulating sleep-wake cycles, controlling food intake or modulating emotional states such as panic or anxiety. The orexin system, consisting of the two orexin-neuropeptides and two G-protein-coupled receptors (the orexin-1 and the orexin-2 receptor) is as well involved in reward and addictive behaviors. The review reflects on the most recent activities in the field of orexin research. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2875 / 2887
页数：13
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