Structure and Biosynthesis of the Antibiotic Bottromycin D

被引：75

作者：

Hou, Yanpeng ^{[1
]}

Tianero, Ma. Diarey B. ^{[2
]}

Kwan, Jason C. ^{[2
]}

Wyche, Thomas P. ^{[1
]}

Michel, Cole R. ^{[1
]}

Ellis, Gregory A. ^{[1
]}

Vazquez-Rivera, Emmanuel ^{[1
]}

Braun, Doug R. ^{[1
]}

Rose, Warren E. ^{[1
]}

Schmidt, Eric W. ^{[2
]}

Bugni, Tim S. ^{[1
]}

机构：

[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 19期

关键词：

MASS-SPECTROMETRY; NATURAL-PRODUCTS; STREPTOMYCES; CLUSTER; CLONING; A(2); MRSA; VRE;

D O I：

10.1021/ol3022758

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway.

引用

页码：5050 / 5053

页数：4

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