Highly enantioselective aldol reaction catalyzed by C2 symmetric organocatalyst

被引：0
|
作者：
Gu, Qing [1 ]
Jiang, Ling-Xia
Wang, Qiong
Wu, Xin-Yan
机构：
[1] E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 28卷 / 08期
关键词：
direct aldol reaction; enantioselective catalysis; organocatalyst; cyclohexanone;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several C-2 symmetric molecules were tested as organocatalysts for the direct catalytic asymmetric aldol reaction of cyclohexanone with 4-nitrobenzaldehyde. (2S,5S)-Pyrrolidine-2,5-dicarboxylic acid afforded the best results for this transformation. The reaction of a series of aromatic aldehydes with cyclohexanone was carried out in DMSO using a catalyst loading of 30 mol% at 10 degrees C, and the aldol adducts were obtained in 87%similar to 99% ee.
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页码：1416 / 1422
页数：7
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