Free-radical scavenging activity of radioprotectors: comparison between clinically used radioprotectors and natural antioxidants

被引：4

作者：

Sueishi, Yoshimi ^{[1
]}

Fujii, Takumi ^{[1
]}

Nii, Risako ^{[1
]}

机构：

[1] Okayama Univ, Dept Chem, Fac Sci, Kita Ku, 3-1-1 Tsushima Naka, Okayama 7008530, Japan

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2020年 / 325卷 / 02期

关键词：

Natural antioxidant; Antioxidant ability; Radioprotective effect; MULTIS; ESR spin trapping; OXIDATIVE STRESS; RADIATION; CAPACITY;

D O I：

10.1007/s10967-020-07258-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Clinically used radioprotectors, amifostine and cysteamine, have been shown to possess free-radical scavenging activities. Natural antioxidants also possess free-radical scavenging activities, some of which have been shown to have radioprotective capability. We carried out a quantitative determination of the scavenging abilities in amifostine and cysteamine and compared the potencies with natural antioxidants by using multiple free-radical scavenging method. Overall, amifostine and cysteamine showed scavenging activity as potent as natural antioxidants. We found a correlation between scavenging activity and radioprotective efficiency that was previously determined in rat thymocytes. These correlations are indicative that natural antioxidants can be effective radioprotectors.

引用

页码：695 / 700

页数：6

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