RETRACTED: Small Protein-Mediated Quorum Sensing in a Gram-Negative Bacterium (Retracted Article)

被引：23

作者：

Han, Sang-Wook ^{[1
,2
]}

Sriariyanun, Malinee ^{[1
,2
]}

Lee, Sang-Won ^{[1
,2
,3
,4
]}

Sharma, Manoj ^{[1
,2
]}

Bahar, Ofir ^{[1
,2
]}

Bower, Zachary ^{[1
,2
]}

Ronald, Pamela C. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Davis, Dept Plant Pathol, Davis, CA 95616 USA

[2] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

[3] Kyung Hee Univ, Dept Plant Mol Syst Biotechnol, Yongin, South Korea

[4] Kyung Hee Univ, Crop Biotech Inst, Yongin, South Korea

来源：

PLOS ONE | 2011年 / 6卷 / 12期

关键词：

ORYZAE PV. ORYZAE; CYCLIC-DI-GMP; XANTHOMONAS-ORYZAE; INNATE IMMUNITY; ESCHERICHIA-COLI; AVRXA21; ACTIVITY; RICE; GENES; RESISTANCE; VIRULENCE;

D O I：

10.1371/journal.pone.0029192

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY(S)22, derived from the Ax21 ((a) under bar ctivator of (X) under barA (21) under bar -mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.

引用

页数：10

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