Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia

被引：14
|
作者：
Hein, JC [1 ]
Sing, A [1 ]
Di Genaro, MS [1 ]
Autenrieth, IB [1 ]
机构：
[1] Univ Munich, Max von Pettenkofer Inst Hyg & Med Mikrobiol, D-80336 Munich, Germany
来源：
MICROBIAL PATHOGENESIS | 2001年 / 31卷 / 04期
关键词：
Yersinia entericolitica; gene deficient mice; interieukin-12; interleukin-18; interferon gamma; bacterial dissemination;
D O I：
10.1006/mpat.2001.0458
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previous results have demonstrated an essential role of gamma interferon (IFN-gamma) in resistance against Yersinia enterocolitica. Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma -inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). The experiments described herein argue for a critical role of both cytokines in protective immune responses against this pathogen. (C) 2001 Academic Press.
引用
收藏
页码：195 / 199
页数：5
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