Imaging Geographic Atrophy in Age-Related Macular Degeneration

被引：59
作者：
Goebel, Arno P.
Fleckenstein, Monika
Schmitz-Valckenberg, Steffen
Brinkmann, Christian K.
Holz, Frank G. [1 ]
机构：
[1] Univ Bonn, Dept Ophthalmol, DE-53127 Bonn, Germany
来源：
OPHTHALMOLOGICA | 2011年 / 226卷 / 04期
关键词：
Age-related macular degeneration; Geographic atrophy; Fundus autofluorescence; Scanning laser ophthalmoscopy; RETINAL-PIGMENT EPITHELIUM; FUNDUS AUTOFLUORESCENCE PATTERNS; IN-VIVO; DISEASE PROGRESSION; JUNCTIONAL ZONE; HIGH-RESOLUTION; HUMAN RPE; LIPOFUSCIN; MACULOPATHY; OCT;
D O I：
10.1159/000330420
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Advances in retinal imaging technology have largely contributed to the understanding of the natural history, prognostic markers and disease mechanisms of geographic atrophy (GA) due to age-related macular degeneration. There is still no therapy available to halt or slow the disease process. In order to evaluate potential therapeutic effects in interventional trials, there is a need for precise quantification of the GA progression rate. Fundus autofluorescence imaging allows for accurate identification and segmentation of atrophic areas and currently represents the gold standard for evaluating progressive GA enlargement. By means of high-resolution spectral-domain optical coherence tomography, distinct microstructural alterations related to GA can be visualized. Copyright (C) 2011 S. Karger AG, Basel
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收藏
页码：182 / 190
页数：9
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