Variation of nitric oxide levels in imported Plasmodium falciparum malaria episodes

被引：0

作者：

De Sousa, Karina ^{[1
]}

Silva, Marcelo S. ^{[1
]}

Tavira, Luis T. ^{[1
]}

机构：

[1] Inst Higiene & Med Trop, Ctr Malaria & Outras Doencas Torp, Unit Ensino & Invest Clin Doencas Trop, P-1349008 Lisbon, Portugal

来源：

AFRICAN JOURNAL OF BIOTECHNOLOGY | 2008年 / 7卷 / 06期

关键词：

nitric oxide; malaria; Plasmodium falciparum; imported malaria;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nitric oxide ( NO) has been recognized during the past two decades as one of the most versatile players in the immune system. Even though the molecular mechanisms responsible by the naturally acquired immunity against malaria are still to be clarified, the production of NO seems to play an important role as a marker for the severity of the disease. In this study we assess the level of nitric oxide in the serum of subjects exposed to malarial settings but who have not become clinically infected by plasmodia parasites. We conclude that NO is in fact a marker of clinical infections but cannot be used as an indicator of the disease's severity.

引用

页码：796 / 799

页数：4

共 8 条

[1]

ANSTEY NM, 1999, AM J TROP MED HYG, V61, P2

[2] Nitric oxide and the immune response [J].

Bogdan, C .

NATURE IMMUNOLOGY, 2001, 2 (10) :907-916

[3]

BRUNET LR, 2001, INT IMMUNOPHARMACOL, P1

[4]

CLARCK IA, 2004, CLIN MICROBIOL REV, V17, P3

[5]

DROMIGNY JA, 2005, T ROY SOC TROP MED H, P99

[6] ROLE OF NITRIC-OXIDE IN PARASITIC INFECTIONS [J].

JAMES, SL .

MICROBIOLOGICAL REVIEWS, 1995, 59 (04) :533-&

[7] Elevated nitric oxide production in children with malarial anemia: Hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells [J].

Keller, CC ;

Kremsner, PG ;

Hittner, JB ;

Misukonis, MA ;

Weinberg, JB ;

Perkins, DJ .

INFECTION AND IMMUNITY, 2004, 72 (08) :4868-4873

[8]

RANJIT MR, 2005, T ROY SOC TROP MED H, P99

← 1 →