Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group

被引：48

作者：

Wang, Yikai ^{[2
]}

Jimenez, Miguel ^{[2
]}

Hansen, Anders S. ^{[2
]}

Raiber, Eun-Ang ^{[1
]}

Schreiber, Stuart L. ^{[1
,2
]}

Young, Damian W. ^{[1
]}

机构：

[1] Broad Inst Harvard & MIT, Chem Biol Program, Cambridge, MA 02142 USA

[2] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 24期

关键词：

DIVERSITY-ORIENTED SYNTHESIS; NITROGEN-CONTAINING HETEROCYCLES; NATURAL-PRODUCT SYNTHESIS; ALKYNE METATHESIS; CROSS-METATHESIS; SKELETAL DIVERSITY; COUPLING REACTION; SMALL-MOLECULE; RCM; ENYNE;

D O I：

10.1021/ja202012s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introducing a silyl group at one of the internal olefin positions in diolefinic substrates results in E-selective olefin formation in macrocyclic ring-forming metathesis. The application of this method to a range of macrocyclic (E)-alkenylsiloxanes is described. Protodesilylation of alkenylsiloxane products yields novel Z-configured macrocycles.

引用

页码：9196 / 9199

页数：4

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