Genetic susceptibility to hereditary non-medullary thyroid cancer

被引：13
|
作者：
Kamani, Tina [1 ]
Charkhchi, Parsa [1 ]
Zahedi, Afshan [1 ]
Akbari, Mohammad R. [1 ,2 ,3 ]
机构：
[1] Univ Toronto, Womens Coll Res Inst, 76 Grenville St,Room 6421, Toronto, ON M5S 1B2, Canada
[2] Univ Toronto, Fac Med, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[3] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5T 3M7, Canada
来源：
HEREDITARY CANCER IN CLINICAL PRACTICE | 2022年 / 20卷 / 01期
关键词：
Thyroid cancer; Familial non-medullary thyroid cancer; Germline mutations; FOXE1; HABP2; SRGAP1; DIRC3; NRG1; GENOME-WIDE ASSOCIATION; POLYGENIC RISK SCORE; COWDEN-LIKE SYNDROME; GERMLINE MUTATION; MULTINODULAR GOITER; DICER1; MUTATIONS; DEGREE RELATIVES; LINKAGE ANALYSIS; COMMON VARIANTS; FOXE1; LOCUS;
D O I：
10.1186/s13053-022-00215-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5-15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Although syndromic NMTC has well-known genetic risk factors, the gene(s) responsible for the vast majority of non-syndromic FNMTC cases are yet to be identified. To date, several candidate genes have been identified as susceptibility genes in hereditary NMTC. This review summarizes genetic predisposition to non-medullary thyroid cancer and expands on the role of genetic variants in thyroid cancer tumorigenesis and the level of penetrance of NMTC-susceptibility genes.
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页数：19
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