Functional Magnetic Resonance Imaging of Working Memory Reveals Frontal Hypoactivation in Middle-Aged Adults with Cognitive Complaints

被引:13
作者
Haley, Andreana P. [1 ,2 ]
Eagan, Danielle E. [1 ]
Gonzales, Mitzi M. [1 ]
Biney, Fedora O. [1 ]
Cooper, Rachel A. [1 ]
机构
[1] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA
[2] Univ Texas Austin, Imaging Res Ctr, Austin, TX 78712 USA
关键词
Subjective cognitive complaints; Cognition; Cardiovascular diseases; fMRI; Working memory; Aging; WHITE-MATTER HYPERINTENSITIES; ARTERY-BYPASS-SURGERY; CARDIOVASCULAR-DISEASE; OLDER-ADULTS; ALZHEIMERS-DISEASE; ENDOTHELIAL FUNCTION; MULTIPLE-SCLEROSIS; IMPAIRMENT; DEMENTIA; PEOPLE;
D O I
10.1017/S1355617711000956
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Older adults with cardiovascular disease (CVD) often complain about cognitive difficulties including reduced processing speed and attention. On cross-sectional examination, such reports relate more closely to mood than to cognitive performance; yet, in longitudinal studies, these complaints have foreshadowed cognitive decline over time. To test the hypothesis that self-reported cognitive difficulties reflect early changes in brain function, we examined cognitive complaints and depression in relation to blood oxygen level dependent (BOLD) response to a cognitive task in middle-aged adults at risk for CVD. Forty-nine adults (ages 40 to 60 years) completed a measure of perceived cognitive dysfunction (Cognitive Difficulties Scale), medical history questionnaire, neuropsychological assessment and functional magnetic resonance imaging (fMRI) during a working memory task. Increased report of cognitive difficulties was significantly associated with weaker task-related activation in the right superior frontal/middle frontal gyms (F(4,44) = 3.26; p = .020, CDS beta = -0.39; p = .009) and the right inferior frontal gyros (F(4,44) = 3.14; p = .024, CDS beta = -0.45; p = .003), independent of age, education, and self-reported depressive symptoms. Lower activation intensity in the right superior frontal gyrus was related to trends toward poorer task performance. Thus, self-reported cognitive difficulties among cognitively normal middle-aged adults may provide important clinical information about early brain vulnerability that should be carefully monitored. (JINS, 2011, 17, 915-924)
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页码:915 / 924
页数:10
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