Synthesis of two isotopically labeled versions of NEDD8-activating enzyme (NAE) inhibitor

被引：5
|
作者：
Li, Yuexian [1 ]
Plesescu, Mihaela [1 ]
Prakash, Shimoga R. [1 ]
机构：
[1] Millennium Pharmaceut Inc, Dept Drug Metab & Phannacokinet, Isotope Chem Grp, Cambridge, MA 02139 USA
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 15期
关键词：
NAE inhibitor; MLN4924; (14)C-6-chloro-7-deazapurine D(8)-(S)-1-aminoindan;
D O I：
10.1016/j.tetlet.2011.02.033
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of two isotopically labeled versions of an investigational NAE inhibitor (MLN4924) is reported. (14)C-MLN4924 was synthesized from (14)C-thiourea in eight steps. D(8)-MLN4924 was prepared from D(9)-3-phenylpropanoic acid in seven steps. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1807 / 1810
页数：4
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