Interaction of Polyalanine α-Helix with Carbon Nanotube

被引：12

作者：

Balamurugan, K. ^{[1
]}

Subramanian, V. ^{[1
]}

机构：

[1] Cent Leather Res Inst, Council Sci & Ind Res, Chem Lab, Madras 600020, Tamil Nadu, India

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2011年 / 7卷 / 01期

关键词：

alpha-Helix; CNT; Hydrogen Bonds; Hydrophobic Interaction; MEMBRANES;

D O I：

10.1166/jbn.2011.1216

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The application of carbon nanotubes (CNT) in the area of biology such as Drug delivery vehicle and Biosensors calls for the basic understanding of the CNT's with biological macromolecules like proteins, DNA, Carbohydrates and lipids. CNT is known to be highly hydrophobic in nature. Our study reveals that the inherent hydrophobic nature of CNT is capable of disturbing the a-helical protein secondary structure. Thus our study provides mechanistic understanding of the loss in the alpha-helicity of the proteins in the presence of CNT. Our study reveals that the nanomaterials should be suitably modified for biological applications.

引用

页码：89 / 90

页数：2

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