Anaphylaxis to the Carbohydrate Side Chain Alpha-gal

被引：71

作者：

Platts-Mills, Thomas A. E. ^{[1
]}

Schuyler, Alexander J. ^{[1
]}

Tripathi, Anubha ^{[1
]}

Commins, Scott P. ^{[1
]}

机构：

[1] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA 22908 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2015年 / 35卷 / 02期

关键词：

Delayed anaphylaxis; Alpha-gal; Ticks; Red-meat allergy; Cetuximab; RED MEAT ALLERGY; MAMMALIAN MEAT; ANTI-GALACTOSE-ALPHA-1,3-GALACTOSE IGE; MASS-SPECTROMETRY; TICKS ACARI; GALACTOSE-ALPHA-1,3-GALACTOSE; SENSITIZATION; ANTIBODIES; CETUXIMAB; EPITOPE;

D O I：

10.1016/j.iac.2015.01.009

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In 2007, the monoclonal antibody cetuximab caused severe hypersensitivity reactions during the first infusion in a region of the southeastern United States. Investigation of pretreatment sera established that they contained immunoglobulin (Ig) E against the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal), which is present on the Fab of cetuximab. Alpha-gal is a blood group substance of nonprimate mammals. These IgE antibodies are also associated with delayed anaphylaxis to red meat (ie, to meat or organs of animals that carry this oligosaccharide). Evidence shows that the primary cause of these IgE antibodies is bites from the tick Amblyomma americanum or its larvae.

引用

页码：247 / +

页数：15

共 46 条

[1] Cat IgA, representative of new carbohydrate cross-reactive allergens [J].

Adedoyin, Justus ;

Gronlund, Hans ;

Oman, Hans ;

Johansson, S. G. O. ;

van Hage, Marianne .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (03) :640-645

[2] Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α1,3-galactose [J].

Arkestal, Kurt ;

Sibanda, Elopy ;

Thors, Cecilia ;

Troye-Blomberg, Marita ;

Mduluza, Takafira ;

Valenta, Rudolf ;

Gronlund, Hans ;

van Hage, Marianne .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (04) :1024-1028

[3] Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques [J].

Ayoub, Daniel ;

Jabs, Wolfgang ;

Resemann, Anja ;

Evers, Waltraud ;

Evans, Catherine ;

Main, Laura ;

Baessmann, Carsten ;

Wagner-Rousset, Elsa ;

Suckau, Detlev ;

Beck, Alain .

MABS, 2013, 5 (05) :699-710

[4]

Brockow K, 2014, J ALLERGY CLIN IMMUN

[5] Peanut allergy: Effect of environmental peanut exposure in children with filaggrin loss-of-function mutations [J].

Brough, Helen A. ;

Simpson, Angela ;

Makinson, Kerry ;

Hankinson, Jenny ;

Brown, Sara ;

Douiri, Abdel ;

Belgrave, Danielle C. M. ;

Penagos, Martin ;

Stephens, Alick C. ;

McLean, W. H. Irwin ;

Turcanu, Victor ;

Nicolaou, Nicolaos ;

Custovic, Adnan ;

Lack, Gideon .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (04) :867-U472

[6]

Burke GS, 2005, EMERG INFECT DIS, V11, P36

[7] Gelatin-containing sweets can elicit anaphylaxis in a patient with sensitization to galactose-α-1,3-galactose [J].

Caponetto, Patricia ;

Fischer, Joerg ;

Biedermann, Tilo .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2013, 1 (03) :302-303

[8] Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose [J].

Chung, Christine H. ;

Mirakhur, Beloo ;

Chan, Emily ;

Le, Quynh-Thu ;

Berlin, Jordan ;

Morse, Michael ;

Murphy, Barbara A. ;

Satinover, Shama M. ;

Hosen, Jacob ;

Mauro, David ;

Slebos, Robbert J. ;

Zhou, Qinwei ;

Gold, Diane ;

Hatley, Tina ;

Hicklin, Daniel J. ;

Platts-Mills, Thomas A. E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) :1109-1117

[9] Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose [J].

Commins, Scott P. ;

James, Hayley R. ;

Stevens, Whitney ;

Pochan, Shawna L. ;

Land, Michael H. ;

King, Carol ;

Mozzicato, Susan ;

Platts-Mills, Thomas A. E. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (01) :108-+

[10] The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose [J].

Commins, Scott P. ;

James, Hayley R. ;

Kelly, Libby A. ;

Pochan, Shawna L. ;

Workman, Lisa J. ;

Perzanowski, Matthew S. ;

Kocan, Katherine M. ;

Fahy, John V. ;

Nganga, Lucy W. ;

Ronmark, Eva ;

Cooper, Philip J. ;

Platts-Mills, Thomas A. E. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (05) :1286-U310

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