Initial serum GM-CSF levels are associated with the severity of cerebral small vessel disease in microscopic polyangiitis patients

被引：1

作者：

Ota, Shin ^{[1
]}

Kotani, Takuya ^{[2
]}

Matsuda, Shogo ^{[2
]}

Nishioka, Daisuke ^{[3
]}

Masuda, Yuichi ^{[1
]}

Unoda, Kiichi ^{[4
]}

Hosokawa, Takafumi ^{[1
]}

Ishida, Shimon ^{[1
]}

Takeuchi, Tohru ^{[2
]}

机构：

[1] Osaka Med Coll, Dept Internal Med 4, Div Neurol, Takatsuki, Osaka 5698686, Japan

[2] Osaka Med Coll, Dept Internal Med 4, Div Rheumatol, Takatsuki, Osaka 5698686, Japan

[3] Osaka Med & Pharmaceut Univ, Res & Dev Ctr, Dept Med Stat, Takatsuki, Osaka 5698686, Japan

[4] Mishima Minami Hosp, Dept Internal Med, Osaka Med Coll, Takatsuki, Osaka 5698686, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 359卷

关键词：

White matter hyperintensities; Cerebral small vessel disease; Microscopic polyangiitis; Brain magnetic resonance imaging; COLONY-STIMULATING FACTOR; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; WHITE-MATTER; RATING-SCALE; HYPERINTENSITIES; INFLAMMATION; THERAPY; STROKE; INJURY; RISK;

D O I：

10.1016/j.jneuroim.2021.577671

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum cytokine levels were comprehensively measured, and the association with cerebrovascular lesions on brain magnetic resonance imaging (MRI) in microscopic polyangiitis (MPA) patients was investigated. The initial serum granulocyte-macrophage colony-stimulating factor (GM-CSF) levels were significantly higher in the highgrade white matter hyperintensities (WMH) group than those in the low-grade WMH group. In multivariate analyses, high serum levels of GM-CSF were independently associated with high-grade WMH. The initial serum GM-CSF levels correlated positively with the Birmingham Vasculitis Activity Score and semi-quantitative scales of WMH. The initial serum GM-CSF levels were associated with the severity of WMH in MPA patients.

引用

页数：8

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