Arterial stiffness is associated with target organ damage in subjects with pre-hypertension

被引:12
作者
Wu, Shaoyun [1 ]
Chen, Dubo [2 ]
Zeng, Xun [3 ]
Wen, Junmin [4 ]
Zhou, Chuzhi [4 ]
Xiao, Ke [5 ]
Hu, Peng [6 ]
Chen, Weixin [4 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Outpatient, Guangzhou, Guangdong, Peoples R China
[4] Shenzhen Sun Yat Sen Cardiovasc Hosp, Dept Intens Unit, Shenzhen, Peoples R China
[5] Shenzhen Sun Yat Sen Cardiovasc Hosp, Dept Cardiol, Shenzhen, Peoples R China
[6] Fifth Subsidiary Sun Yat Sen Univ Hosp, Dept Cardiol, Zhuhai 51000, Peoples R China
关键词
pre-hypertension; target organ damage; arterial stiffness; CARDIOVASCULAR-DISEASE RISK; JOINT NATIONAL COMMITTEE; BLOOD-PRESSURE; HYPERTENSION; METAANALYSIS; ALBUMINURIA; PREVALENCE; ADULTS;
D O I
10.5114/aoms.2017.69240
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Present study was to evaluate whether increased arterial stiffness was associated with target organ damage in pre-hypertensive subjects. Material and methods: Pre-hypertensive subjects enrolled and echocardiography was used to evaluate left ventricular hypertrophy (LVH) and the first morning urine was collected to evaluate albumin and creatinine ratio (ALB/Cr ratio). Carotid-femoral pulse wave velocity (cf-PWV) was measured. Results: A total of 420 subjects were recruited and mean age was 42.6 years. Mean systolic/diastolic blood pressure (SBP/DBP) were 130 +/- 9 mm Hg and 85 +/- 4 mm Hg. The prevalence of albuminuria and left ventricular hypertrophy was 8.6 % and 11.7 %. Mean cf-PWV was 9.2 +/- 1.0 m/s, with arterial stiffness prevalence was 8.8%. Subjects with arterial stiffness had higher cf-PWV value (10.6 +/- 0.4 m/s vs. 8.7 +/- 0.6 m/s, p < 0.05), and ALB/Cr ratio (28.3 +/- 13.2 mu g/mg vs. 23.1 +/- 11.4 mu g/mg, p < 0.05). Overall, with multivariate regression analysis, aging and arterial stiffness were significantly associated with pre-hypertension. With stepwise adjusted for potential covariates including age, male gender, fasting plasma glucose, presence of current cigarette smoking, dyslipidemia, statins and SBP, increased cf-PWV remained independently associated with left ventricular hypertrophy and albuminuria, with an increased odds of 41 % and 24 % (p < 0.05), respectively. Conclusions: In pre-hypertensive subjects, arterial stiffness is independently associated with LVH and albuminuria and cf-PWV may be a useful marker to identify target organ damage in pre-hypertensive subjects.
引用
收藏
页码:1374 / 1380
页数:7
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