Gold-cluster degradation by the transition of B-DNA into A-DNA and the formation of nanowires

被引：78

作者：

Liu, YP ^{[1
]}

Meyer-Zaika, W

Franzka, S

Schmid, G

Tsoli, M

Kuhn, H

机构：

[1] Univ Essen Gesamthsch, Inst Anorgan Chem, D-45117 Essen, Germany

[2] Univ Essen Gesamthsch, Inst Phys Chem, D-45117 Essen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 25期

关键词：

antitumor agents; DNA structures; electron microscopy; gold; metal-DNA interactions;

D O I：

10.1002/anie.200250235

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Making 13 from 55: Au55 nanoclusters that interact with the major groove of B-DNA (see energy-minimized structure), are broken down into Au13 clusters by the transformation of B-DNA into A-DNA, during which the major groove shrinks dramatically. This transformation, which results in the formation of Au13 wires, is initiated by the dehydration of the B-DNA under the conditions required for electron microscopy.

引用

页码：2853 / 2857

页数：5

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