Retinoids in the pancreas

被引:32
作者
Brun, Pierre-Jacques [1 ]
Wongsiriroj, Nuttaporn [2 ]
Blaner, William S. [1 ]
机构
[1] Columbia Univ, Coll Phys & Surg, Dept Med, 650 W 168th St, New York, NY 10032 USA
[2] Mahidol Univ, Inst Mol Biosci, Nakhon Pathom, Thailand
基金
美国国家卫生研究院;
关键词
Islets; diabetes; insulin; glucagon; pancreatic cancer; VITAMIN-A-DEFICIENCY; STIMULATED INSULIN-SECRETION; BETA-CELL MASS; ACID RECEPTOR; 9-CIS-RETINOIC ACID; STELLATE CELLS; GLUCAGON-SECRETION; BINDING PROTEINS; PROGENITOR CELLS; GENE-EXPRESSION;
D O I
10.3978/j.issn.2304-3881.2015.09.03
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Retinoids (vitamin A and its natural and synthetic analogs) are required by most tissues for maintaining the normal health of the tissue. This is certainly true for the pancreas. The recent literature is convincing that retinoids are needed by the adult to assure normal pancreatic endocrine functions, especially those of the alpha- and beta-cells. It is also well established that retinoids are required to insure normal pancreas development in utero, including the development of the endocrine pancreas. The actions of retinoids for maintaining normal pancreatic islet functions has drawn considerable research interest from investigators interested in understanding and treating metabolic disease. Pancreatic retinoids are also of interest to investigators studying the origins of pancreatic disease, including the development of pancreatic fibrosis and its sequelae. This research interest is focused on pancreatic stellate cells (PSCs) which store retinoids and possess the metabolic machinery needed to metabolize retinoids. The literature on pancreatic disease and retinoids suggests that there is an association between impairments in pancreatic retinoid storage and metabolism and the development of pancreatic disease. These topics will be considered in this review.
引用
收藏
页码:1 / 14
页数:14
相关论文
共 63 条
[1]   Vitamin A and retinoid signaling: genomic and nongenomic effects [J].
Al Tanoury, Ziad ;
Piskunov, Aleksandr ;
Rochette-Egly, Cecile .
JOURNAL OF LIPID RESEARCH, 2013, 54 (07) :1761-1775
[2]   GROWTH, APPETITE, SEQUENCE OF PATHOLOGICAL SIGNS AND SURVIVAL FOLLOWING THE INDUCTION OF RAPID, SYNCHRONOUS VITAMIN-A-DEFICIENCY IN THE RAT [J].
ANZANO, MA ;
LAMB, AJ ;
OLSON, JA .
JOURNAL OF NUTRITION, 1979, 109 (08) :1419-1431
[3]   Pancreatic stellate cells: a starring role in normal and diseased pancreas [J].
Apte, Minoti V. ;
Pirola, Romano C. ;
Wilson, Jeremy S. .
FRONTIERS IN PHYSIOLOGY, 2012, 3
[4]   Gene expression regulation by retinoic acid [J].
Balmer, JE ;
Blomhoff, R .
JOURNAL OF LIPID RESEARCH, 2002, 43 (11) :1773-1808
[5]   All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor [J].
Berry, Daniel C. ;
Noy, Noa .
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (12) :3286-3296
[6]   Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage [J].
Blaner, William S. ;
O'Byrne, Sheila M. ;
Wongsiriroj, Nuttaporn ;
Kluwe, Johannes ;
D'Ambrosio, Diana M. ;
Jiang, Hongfeng ;
Schwabe, Robert F. ;
Hillman, Elizabeth M. C. ;
Piantedosi, Roseann ;
Libien, Jenny .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (06) :467-473
[7]   Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival [J].
Bleul, Tim ;
Ruehl, Ralph ;
Bulashevska, Svetlana ;
Karakhanova, Svetlana ;
Werner, Jens ;
Bazhin, Alexandr V. .
MOLECULAR CARCINOGENESIS, 2015, 54 (09) :870-879
[8]   Effects of retinoids and thiazolidinediones on proliferation, insulin release, insulin mRNA, GLUT 2 transporter protein and mRNA of INS-1 cells [J].
Blumentrath, J ;
Neye, H ;
Verspohl, EJ .
CELL BIOCHEMISTRY AND FUNCTION, 2001, 19 (03) :159-169
[9]   Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass [J].
Brun, Pierre-Jacques ;
Grijalva, Ambar ;
Rausch, Richard ;
Watson, Elizabeth ;
Yuen, Jason J. ;
Das, Bhaskar C. ;
Shudo, Koichi ;
Kagechika, Hiroyuki ;
Leibel, Rudolph L. ;
Blaner, William S. .
FASEB JOURNAL, 2015, 29 (02) :671-683
[10]   Retinoids: Potent regulators of metabolism [J].
Brun, Pierre-Jacques ;
Yang, Kryscilla Jian Zhang ;
Lee, Seung-Ah ;
Yuen, Jason J. ;
Blaner, William S. .
BIOFACTORS, 2013, 39 (02) :151-163