PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis

被引：293

作者：

Song, Jinsoo ^{[1
]}

Kim, Dongkyun ^{[1
]}

Han, Jiyeon ^{[1
]}

Kim, Yunha ^{[1
]}

Lee, Myeungsu ^{[2
]}

Jin, Eun-Jung ^{[1
]}

机构：

[1] Wonkwang Univ, Dept Biol Sci, Coll Nat Sci, Iksan 570749, Chunbuk, South Korea

[2] Wonkwang Univ, Div Rheumatol, Dept Internal Med, Sch Med, Iksan 570749, Chunbuk, South Korea

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2015年 / 15卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

LncRNA; Hotair; BMCS; Exosome; Rheumatoid arthritis; Matrix metalloprotease; LONG NONCODING RNAS; CELLS;

D O I：

10.1007/s10238-013-0271-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.

引用

页码：121 / 126

页数：6

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