Combination of microRNA therapeutics with small-molecule anticancer drugs: Mechanism of action and co-delivery nanocarriers

被引：121

作者：

Dai, Xin ^{[1
]}

Tan, Chalet ^{[1
]}

机构：

[1] Mercer Univ, Coll Pharm, Dept Pharmaceut Sci, Canc Nanomed Lab, Atlanta, GA 30341 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 81卷

关键词：

MicroRNA mimic; Anti-miR; Small-molecule anticancer drug; Co-delivery; Nanocarrier; Combination therapy; MODULATES MULTIDRUG-RESISTANCE; BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR GENE; HUMAN GASTRIC-CANCER; HUMAN LUNG CANCERS; DOWN-REGULATION; PANCREATIC-CANCER; SIRNA DELIVERY; POOR-PROGNOSIS;

D O I：

10.1016/j.addr.2014.09.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MicroRNAs (miRNAs) regulate multiple molecular pathways vital for the hallmarks of cancer with a high degree of biochemical specificity and potency. By restoring tumor suppressive miRNAs or ablating oncomiRs, miRNA-based therapies can sensitize cancer cells to conventional cytotoxins and the molecularly targeted drugs by promoting apoptosis and autophagy, reverting epithelial-to-mesenchymal transition, suppressing tumor angiogenesis, and downregulating efflux transporters. The development of miRNA-based therapeutics in combination with small-molecule anticancer drugs provides an unprecedented opportunity to counteract chemoresistance and improve treatment outcome in a broad range of human cancers. This review summarizes the mechanisms and advantages for the combination therapies involving miRNAs and small-molecule drugs, as well as the recent advances in the co-delivery nanocarriers for these agents. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：184 / 197

页数：14

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