Pharmacological Functionalization of Protein-Based Nanorobots as a Novel Tool for Drug Delivery in Cancer

被引：1
|
作者：
Tavassoly, Omid [4 ]
Tavassoly, Iman [1 ,2 ,3 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, New York, NY 10029 USA
[2] Kavli Inst Theoret Phys, Cellular Energet Program, Santa Barbara, CA USA
[3] C2i Genom, 180 Varick St,Sixth Fl, New York, NY 10014 USA
[4] Simon Fraser Univ, Dept Chem, Columbia, BC V5A 1S6, Canada
来源：
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2021年 / 4卷 / 04期
基金：
美国国家科学基金会;
关键词：
coiled-coil protein origami; nanorobot; pharmacological functionalization; protein kinase A; IN-VITRO; DESIGN; PHOSPHORYLATION; STABILITY;
D O I：
10.1021/acsptsci.1c00128
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein origami and discuss a proposed programmable protein origami structure, switchable by a protein kinase A/phosphatase switch, as an example of functionalization for designing future protein nanorobots.
引用
收藏
页码：1463 / 1467
页数：5
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