Structure of single-wall peptide nanotubes: in situ flow aligning X-ray diffraction

被引：57

作者：

Castelletto, Valeria ^{[1
]}

Nutt, David R. ^{[1
]}

Hamley, Ian W. ^{[1
,4
]}

Bucak, Seyda ^{[2
]}

Cenker, Celen ^{[3
]}

Olsson, Ulf ^{[3
]}

机构：

[1] Univ Reading, Dept Chem, Whiteknights Reading RG6 6AD, England

[2] Yeditepe Univ, Dept Chem Engn, Istanbul, Turkey

[3] Lund Univ, S-22100 Lund, Sweden

[4] Diamond Light Source, Didcot OX11 0DE, Oxon, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 34期

基金：

英国工程与自然科学研究理事会;

关键词：

AMYLOID FIBRILS; SOLVENT; ASSEMBLIES; CORE;

D O I：

10.1039/c0cc00212g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of single wall peptide nanotubes is presented for the model surfactant-like peptide A(6)K. Capillary flow alignment of a sample in the nematic phase at high concentration in water leads to oriented X-ray diffraction patterns. Analysis of these, accompanied by molecular dynamics simulations, suggests the favourable self-assembly of antiparallel peptide dimers into beta-sheet ribbons that wrap helically to form the nanotube wall.

引用

收藏

页码：6270 / 6272

页数：3

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