Hyperbilirubinemia in Preterm Neonates

被引：59

作者：

Bhutani, Vinod K. ^{[1
]}

Wong, Ronald J. ^{[1
]}

Stevenson, David K. ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Neonatal & Dev Med,Sch Med, Stanford Childrens Hlth,Lucile Packard Childrens, Stanford, CA 94305 USA

来源：

CLINICS IN PERINATOLOGY | 2016年 / 43卷 / 02期

关键词：

Bilirubin; Reactive oxygen species; Photosensitivity; BIND; Antioxidant properties; SERUM BILIRUBIN CONCENTRATION; CHRONIC KIDNEY-DISEASE; BRAIN-STEM RESPONSES; RISK-FACTORS; NEURODEVELOPMENTAL OUTCOMES; EXCHANGE-TRANSFUSION; UNBOUND BILIRUBIN; BOUND BILIRUBIN; KERNICTERUS; INFANTS;

D O I：

10.1016/j.clp.2016.01.001

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Preterm neonates with increased bilirubin production loads are more likely to sustain adverse outcomes due to either neurotoxicity or overtreatment with phototherapy and/or exchange transfusion. Clinicians should rely on expert consensus opinions to guide timely and effective interventions until there is better evidence to refine bilirubin-induced neurologic dysfunction or benefits of bilirubin. In this article, we review the evolving evidence for bilirubin-induced brain injury in preterm infants and highlight the clinical approaches that minimize the risk of bilirubin neurotoxicity.

引用

页码：215 / +

页数：19