Natural product analogues: towards a blueprint for analogue-focused synthesis

被引：38

作者：

Bebbington, Magnus W. P. ^{[1
]}

机构：

[1] Heriot Watt Univ, Organ Chem, Edinburgh, Midlothian, Scotland

来源：

CHEMICAL SOCIETY REVIEWS | 2017年 / 46卷 / 16期

关键词：

BIOMIMETIC TOTAL-SYNTHESIS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; PRECURSOR-DIRECTED BIOSYNTHESIS; CELL-MIGRATION INHIBITORS; DIVERTED TOTAL-SYNTHESIS; BIOLOGICAL EVALUATION; COLLECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; CONCISE SYNTHESIS;

D O I：

10.1039/c6cs00842a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

引用

页码：5059 / 5109

页数：51

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