Rhenium- and Manganese-Catalyzed Selective Alkenylation of Indoles

被引：47

作者：

Wang, Chengming ^{[1
]}

Rueping, Magnus ^{[1
,2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] KAUST, KAUST Catalysis Ctr KCC, Thuwal 239556900, Saudi Arabia

来源：

CHEMCATCHEM | 2018年 / 10卷 / 12期

关键词：

alkenylation; C-H activation; indoles; Manganese; Rhenium; C-H BOND; DIELS-ALDER REACTIONS; CARBON-CARBON BONDS; 4+2 ANNULATION; ALKYNES; ACTIVATION; FUNCTIONALIZATION; HYDROARYLATION; OLEFINATION; ALDEHYDES;

D O I：

10.1002/cctc.201800553

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient rhenium-catalyzed regioselective C-H bond alkenylation of indoles is reported. The protocol operates well for internal as well as terminal alkynes, affording products in good to excellent yields. Furthermore, a manganese-catalyzed, acid free, regioselective C2-alkenylation of indoles with internal alkynes is described. The directing groups can be easily removed after the reaction and the resulting products can be used as valuable building blocks for the synthesis of diverse heterocyclic compounds.

引用

页码：2681 / 2685

页数：5