Antithrombotic therapy in patients with diabetes mellitus Diabetes mellitus and cardiovascular diseases

被引：0

作者：

Heger, Lukas Andreas ^{[1
]}

Duerschmied, Daniel ^{[1
]}

机构：

[1] Univ Herzzentrum Freiburg Bad Krozingen, Kardiol & Angiol 1, Hugstetter Str 55, D-79106 Freiburg, Germany

来源：

DIABETOLOGE | 2021年 / 17卷 / 08期

关键词：

Atherosclerosis; Chronic coronary syndrome; COMPASS trial; Peripheral artery disease; Myocardial infarction; ARTERY-DISEASE; ISCHEMIC EVENTS; RIVAROXABAN; ASPIRIN; CORONARY; OUTCOMES; RISK;

D O I：

10.1007/s11428-021-00796-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease (CVD) is the leading cause of death in patients with diabetes mellitus (DM) and despite modern therapeutic strategies, patients with DM have at least a two-fold increased risk of cardiovascular events. The prothrombotic state in patients with DM is associated with multiple determinants such as platelet alterations and endothelial dysfunction. Thus, proper antithrombotic strategies to reduce the risk of CVD in this population are critical. Recently, the COMPASS trial showed a net clinical benefit of the combination therapy of low-dose rivaroxaban plus acetylsalicylic acid, called dual antithrombotic therapy (DAT), when compared to acetylsalicylic acid in patients with chronic vascular disease (either peripheral artery disease [PAD] or chronic coronary syndrome [CCS]) and DM, even when it comes to all-cause mortality. Therefore, guidelines currently advise to evaluate DAT or dual antiplatelet therapy (DAPT) for high-risk patients with DM.

引用

页码：825 / 833

页数：9

共 24 条

[1] Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial [J].

Anand, Sonia S. ;

Bosch, Jackie ;

Eikelboom, John W. ;

Connolly, Stuart J. ;

Diaz, Rafael ;

Widimsky, Peter ;

Aboyans, Victor ;

Alings, Marco ;

Kakkar, Ajay K. ;

Keltai, Katalin ;

Maggioni, Aldo P. ;

Lewis, Basil S. ;

Stoerk, Stefan ;

Zhu, Jun ;

Lopez-Jaramillo, Patricio ;

O'Donnell, Martin ;

Commerford, Patrick J. ;

Vinereanu, Dragos ;

Pogosova, Nana ;

Ryden, Lars ;

Fox, Keith A. A. ;

Bhatt, Deepak L. ;

Misselwitz, Frank ;

Varigos, John D. ;

Vanassche, Thomas ;

Avezum, Alvaro A. ;

Chen, Edmond ;

Branch, Kelley ;

Leong, Darryl P. ;

Bangdiwala, Shrikant I. ;

Hart, Robert G. ;

Yusuf, Salim .

LANCET, 2018, 391 (10117) :219-229

[2]

[Anonymous], 2019, IDF Diabetes Atlas 2019, VNinth

[3] Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease [J].

Bansilal, Sameer ;

Bonaca, Marc P. ;

Cornel, Jan H. ;

Storey, Robert F. ;

Bhatt, Deepak L. ;

Steg, Gabriel ;

Im, Kyungah ;

Murphy, Sabina A. ;

Angiolillo, Dominick J. ;

Kiss, Robert G. ;

Parkhomenko, Alexander N. ;

Lopez-Sendon, Jose ;

Isaza, Daniel ;

Goudev, Assen ;

Kontny, Frederic ;

Held, Peter ;

Jensen, Eva C. ;

Braunwald, Eugene ;

Sabatine, Marc S. ;

Ophuis, A. J. Oude .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (05) :489-496

[4] Rivaroxaban in Peripheral Artery Disease after Revascularization [J].

Bonaca, Marc P. ;

Bauersachs, Rupert M. ;

Anand, Sonia S. ;

Debus, E. Sebastian ;

Nehler, Mark R. ;

Patel, Manesh R. ;

Fanelli, Fabrizio ;

Capell, Warren H. ;

Diao, Lihong ;

Jaeger, Nicole ;

Hess, Connie N. ;

Pap, Akos F. ;

Kittelson, John M. ;

Gudz, Ivan ;

Matyas, Lajos ;

Krievins, Dainis K. ;

Diaz, Rafael ;

Brodmann, Marianne ;

Muehlhofer, Eva ;

Haskell, Lloyd P. ;

Berkowitz, Scott D. ;

Hiatt, William R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (21) :1994-2004

[5] Rationale and design for the Vascular Outcomes study of ASA along with rivaroxaban in endovascular or surgical limb revascularization for peripheral artery disease (VOYAGER PAD) [J].

Capell, Warren H. ;

Bonaca, Marc P. ;

Nehler, Mark R. ;

Chen, Edmond ;

Kittelson, John M. ;

Anand, Sonia S. ;

Berkowitz, Scott D. ;

Debus, Eike Sebastian ;

Fanelli, Fabrizio ;

Haskell, Lloyd ;

Patel, Manesh R. ;

Bauersachs, Rupert ;

Hiatt, William R. .

AMERICAN HEART JOURNAL, 2018, 199 :83-91

[6] Impact of Diabetes Mellitus on Hospitalization for Heart Failure, Cardiovascular Events, and Death Outcomes at 4 Years From the Reduction of Atherothrombosis for Continued Health (REACH) Registry [J].

Cavender, Matthew A. ;

Steg, Ph Gabriel ;

Smith, Sidney C., Jr. ;

Eagle, Kim ;

Ohman, E. Magnus ;

Goto, Shinya ;

Kuder, Julia ;

Im, Kyungah ;

Wilson, Peter W. F. ;

Bhatt, Deepak L. .

CIRCULATION, 2015, 132 (10) :923-931

[7] Performance of PRECISE-DAPT Score for Predicting Bleeding Complication During Dual Antiplatelet Therapy [J].

Choi, Sun Young ;

Kim, Moo Hyun ;

Cho, Young-Rak ;

Park, Jong Sung ;

Lee, Kwang Min ;

Park, Tae-Ho ;

Yun, Sung-Cheol .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2018, 11 (12)

[8]

Collet JP, 2021, REV ESP CARDIOL, V74, DOI [10.1016/j.rec.2021.05.002, 10.1093/eurheartj/ehaa575]

[9] 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD [J].

Cosentino, Francesco ;

Grant, Peter J. ;

Aboyans, Victor ;

Bailey, Clifford J. ;

Ceriello, Antonio ;

Delgado, Victoria ;

Federici, Massimo ;

Filippatos, Gerasimos ;

Grobbee, Diederick E. ;

Hansen, Tina Birgitte ;

Huikuri, Heikki, V ;

Johansson, Isabelle ;

Juni, Peter ;

Lettino, Maddalena ;

Marx, Nikolaus ;

Mellbin, Linda G. ;

Ostgren, Carl J. ;

Rocca, Bianca ;

Roffi, Marco ;

Sattar, Naveed ;

Seferovic, Petar M. ;

Sousa-Uva, Miguel ;

Valensi, Paul ;

Wheeler, David C. ;

Piepoli, Massimo Francesco ;

Birkeland, Kare, I ;

Adamopoulos, Stamatis ;

Ajjan, Ramzi ;

Avogaro, Angelo ;

Baigent, Colin ;

Brodmann, Marianne ;

Bueno, Hector ;

Ceconi, Claudio ;

Chioncel, Ovidiu ;

Coats, Andrew ;

Collet, Jean-Philippe ;

Collins, Peter ;

Cosyns, Bernard ;

Di Mario, Carlo ;

Fisher, Miles ;

Fitzsimons, Donna ;

Halvorsen, Sigrun ;

Hansen, Dominique ;

Hoes, Arno ;

Holt, Richard I. G. ;

Home, Philip ;

Katus, Hugo A. ;

Khunti, Kamlesh ;

Komajda, Michel ;

Lambrinou, Ekaterini .

EUROPEAN HEART JOURNAL, 2020, 41 (02) :255-323

[10] Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease [J].

Eikelboom, J. W. ;

Connolly, S. J. ;

Bosch, J. ;

Dagenais, G. R. ;

Hart, R. G. ;

Shestakovska, O. ;

Diaz, R. ;

Alings, M. ;

Lonn, E. M. ;

Anand, S. S. ;

Widimsky, P. ;

Hori, M. ;

Avezum, A. ;

Piegas, L. S. ;

Branch, K. R. H. ;

Probstfield, J. ;

Bhatt, D. L. ;

Zhu, J. ;

Liang, Y. ;

Maggioni, A. P. ;

Lopez-Jaramillo, P. ;

O'Donnell, M. ;

Kakkar, A. K. ;

Fox, K. A. A. ;

Parkhomenko, A. N. ;

Ertl, G. ;

Stoerk, S. ;

Keltai, M. ;

Ryden, L. ;

Pogosova, N. ;

Dans, A. L. ;

Lanas, F. ;

Commerford, P. J. ;

Torp-Pedersen, C. ;

Guzik, T. J. ;

Verhamme, P. B. ;

Vinereanu, D. ;

Kim, J. -H. ;

Tonkin, A. M. ;

Lewis, B. S. ;

Felix, C. ;

Yusoff, K. ;

Steg, P. G. ;

Metsarinne, K. P. ;

Bruns, N. Cook ;

Misselwitz, F. ;

Chen, E. ;

Leong, D. ;

Yusuf, S. ;

Aboyans, V. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (14) :1319-1330

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