Scratching of their skin by NC/Nga mice leads to development of dermatitis

被引：65

作者：

Hashimoto, Y ^{[1
]}

Arai, I ^{[1
]}

Nakanishi, Y ^{[1
]}

Sakurai, TA ^{[1
]}

Nakamura, A ^{[1
]}

Nakaike, S ^{[1
]}

机构：

[1] Taisho Pharmaceut Co Ltd, Med Res Labs, Pharmacol Lab, Kita Ku, Saitama City 3319530, Japan

来源：

LIFE SCIENCES | 2004年 / 76卷 / 07期

关键词：

scratching behavior; itch; atopic dermatitis; NC/Nga mice; trans epidermal water loss;

D O I：

10.1016/j.lfs.2004.07.022

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails. (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a therapeutic treatment by cutting off hind toenails of NC mice with severe dermatitis. In the preventive study, scratching behavior significantly increased in both WIT and WOT after dermatitis induction. Skin severity score. TEWL, number of mast cells and serum IgE concentration statistically increased in WIT but not in WOT after dermatitis induction. Histological changes coincided with the skin severity score in WIT. while no changes were observed in WOT. In the therapeutic study, skin severity score in WOT but not in WIT statistically decreased after cutting off the hind toenails. TEWL and numbers of mast cells in WOT were statistically lower compared with findings in WIT. Thus scratching up the skin with toenails seemed to be the most important factor leading to dermatitis in NC mice. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：783 / 794

页数：12

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