Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy

被引：80
作者：
Chen, Hai-Jun [1 ]
Zhou, Xiao-Bin [1 ]
Wang, Ai-Lan [1 ]
Zheng, Bi-Yuan [1 ]
Yeh, Chih-Kuang [2 ]
Huang, Jian-Dong [1 ]
机构：
[1] Fuzhou Univ, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fuzhou 350116, Fujian, Peoples R China
[2] Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 30013, Taiwan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 145卷
基金：
中国国家自然科学基金;
关键词：
Sono-photodynamic therapy; Sensitizers; RB derivatives; Amphiphilicity; SONODYNAMIC THERAPY; IN-VITRO; CANCER-THERAPY; INTRALESIONAL THERAPY; TUMOR ACCUMULATION; BREAST-CANCER; CELLS; PHTHALOCYANINES; ULTRASOUND; THERAPEUTICS;
D O I：
10.1016/j.ejmech.2017.12.091
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clinical trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacological properties of RB hindered its extensive clinical development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biological characterized. Among them, RBD4 significantly improved cellular uptake and enhanced intracellular ROS generation efficiency upon light and ultra-sound irradiation, resulting in dramatically improved anticancer potency. Notably, RBD4 has a relative potency similar to sinoporphyrin sodium (DVDMS), indicating its further potential application for SPDT. (C) 2018 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：86 / 95
页数：10
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