The Helicobacter pylori Cag Type IV Secretion System

被引：119

作者：

Cover, Timothy L. ^{[1
,2
,3
]}

Lacy, D. Borden ^{[2
,3
]}

Ohi, Melanie D. ^{[4
,5
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA

[3] Vet Affairs Tennessee Valley Healthcare Syst, Nashville, TN 37212 USA

[4] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI USA

来源：

TRENDS IN MICROBIOLOGY | 2020年 / 28卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PATHOGENICITY ISLAND; COUPLING PROTEIN; IN-VIVO; HOST; TRANSLOCATION; EXPRESSION; COLONIZATION; INDUCTION; ANTIGEN; CANCER;

D O I：

10.1016/j.tim.2020.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. pylori Cag T4SS is substantially more complex than that of prototype T4SSs in other bacterial species. In this review, we discuss recent discoveries pertaining to the structure and function of the Cag T4SS and its role in gastric cancer pathogenesis.

引用

页码：682 / 695

页数：14

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