Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease

被引：38

作者：

Antonyova, Veronika ^{[1
,2
]}

Kejik, Zdenek ^{[1
,2
,4
]}

Brogyanyi, Tereza ^{[5
,6
]}

Kaplanek, Robert ^{[1
,2
,3
,4
]}

Pajkova, Martina ^{[1
,2
,3
]}

Talianova, Veronika ^{[1
,2
,3
]}

Hromadka, Robert ^{[1
,2
]}

Masarik, Michal ^{[1
,2
,3
]}

Sykora, David ^{[3
,4
]}

Miksatkova, Lucie ^{[3
,4
]}

Martasek, Pavel ^{[1
,2
]}

Jakubek, Milan ^{[1
,2
,3
,4
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Katerinska 32, Prague 12108 2, Czech Republic

[2] Gen Univ Hosp Prague, Katerinska 32, Prague 12108 2, Czech Republic

[3] Charles Univ Prague, Fac Med 1, BIOCEV, Katerinska 32, Prague 12108 2, Czech Republic

[4] Univ Chem & Technol Prague, Dept Analyt Chem, Tech 5, Prague 16628 6, Czech Republic

[5] Charles Univ Prague, Fac Med 1, Dept Pathol Physiol, Ke Karlovu 2, Prague 12100 2, Czech Republic

[6] Gen Univ Hosp Prague, Ke Karlovu 2, Prague 12100 2, Czech Republic

来源：

DNA REPAIR | 2020年 / 91-92卷

关键词：

Alzheimer's disease; Parkinson's disease; Mitochondrial DNA disturbances; Neuroinflammation; Peptide and protein aggregation; Oxidative stress; MITOCHONDRIAL-DNA HAPLOGROUPS; LEWY BODY PATHOLOGY; ALPHA-SYNUCLEIN; CEREBROSPINAL-FLUID; JAPANESE CENTENARIANS; NEUROLOGIC DISORDERS; OXIDATIVE DAMAGE; COMMON DELETION; C-ABL; MUTATIONS;

D O I：

10.1016/j.dnarep.2020.102871

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Therefore, their underlying mechanisms are trending topics of study in medicinal research. Numerous studies have evidenced a strong association between mitochondrial DNA disturbances (e.g. oxidative damage, mutations, and methylation shifts) and the initiation and progression of neurodegenerative diseases. Therefore, this review discusses the risk and development of neurodegenerative diseases in terms of disturbances in mitochondrial DNA and as a part of a complex ecosystem that includes other important mechanisms (e.g. neuroinflammation and the misfolding and aggregation of amyloid-beta peptides, alpha-synuclein, and tau proteins). In addition, the influence of individual mitochondrial DNA haplogroups on the risk and development of neurodegenerative diseases is also described and discussed.

引用

页数：13

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