Improved methods to determine radionuclidic purity of F-18 compounds

被引：2

作者：

Jorgensen, Thomas ^{[1
]}

Micheelsen, Mille Ankerstjerne ^{[2
]}

Jensen, Mikael ^{[1
]}

机构：

[1] Tech Univ Denmark, Hevesy Lab, DK-4000 Roskilde, Denmark

[2] Koege Hosp, Dept Clin Physiol & Nucl Med, DK-4600 Koege, Denmark

来源：

APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 03期

关键词：

Radionuclidic purity; F-18; Half-life measurements;

D O I：

10.1016/j.apradiso.2011.10.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Current revisions of monographs for F-18 pharmaceuticals in the European Pharmacopoeia (Ph. Eur.) (Ph. Eur., 2011) call for a radionuclidic purity (RNP) of or better than 99.9%. However, the current method is not sufficient nor effective for testing this required RNP level. We present a theoretical model leading to a practical procedure for a simple test of RNP for F-18 compounds that tells whether or not the sample is pure with a statistical confidence of 97.5% (P=0.975). (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：430 / 437

页数：8