Vascular Disease in Diabetic Women: Why Do They Miss the Female Protection?

被引：32

作者：

Villela Dantas, Ana Paula ^{[1
,2
]}

Fortes, Zuleica Bruno ^{[3
]}

Catelli de Carvalho, Maria Helena ^{[3
]}

机构：

[1] Hosp Clin Barcelona, IDIBAPS, Expt Cardiol Div, E-08036 Barcelona, Spain

[2] Hosp Clin Barcelona, IDIBAPS 404, Inst Clin Torax, C Casanova Lab 143, E-08036 Barcelona, Spain

[3] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Lab Hypertens, BR-2415 Sao Paulo, Brazil

来源：

EXPERIMENTAL DIABETES RESEARCH | 2012年

基金：

巴西圣保罗研究基金会;

关键词：

ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT RELAXATION; MESSENGER-RNA EXPRESSION; POSTMENOPAUSAL WOMEN; INSULIN-RESISTANCE; GENDER-DIFFERENCES; PLUS PROGESTIN; LOCAL-DELIVERY; SEX-HORMONES;

D O I：

10.1155/2012/570598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gender plays a pivotal role in the onset as well as in the progression of the cardiovascular disease with a higher morbidity and mortality being detected in men with respect to women. Type 2 Diabetes Mellitus (T2DM) may reduce gender-related differences in the prevalence of cardiovascular disease by fading the vascular protective effects afforded by estrogen in females. This article will discuss the role of sex and sex hormones on the incidence and mechanisms involved in vascular dysfunction associated to T2DM, which might explain why women with T2DM lack the vascular protection.

引用

页数：10

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