Deep Brain Stimulation for Intractable Psychiatric Disorders

被引：59

作者：

Goodman, Wayne K. ^{[1
]}

Alterman, Ron L. ^{[2
]}

机构：

[1] Mt Sinai Sch Med, Friedman Brain Inst, Dept Psychiat, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Friedman Brain Inst, Dept Neurosurg, New York, NY 10029 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 63 | 2012年 / 63卷

关键词：

depression; obsessive-compulsive disorder (OCD); psychiatric disorders; OBSESSIVE-COMPULSIVE-DISORDER; TREATMENT-RESISTANT DEPRESSION; TERM-FOLLOW-UP; TRANSCRANIAL MAGNETIC STIMULATION; HARDWARE-RELATED COMPLICATIONS; VAGUS NERVE-STIMULATION; LONG-TERM; NUCLEUS-ACCUMBENS; ELECTROCONVULSIVE-THERAPY; ELECTRICAL-STIMULATION;

D O I：

10.1146/annurev-med-052209-100401

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Deep brain stimulation (DBS) has virtually replaced ablative neurosurgery for use in medication-refractory movement disorders. DBS is now being studied in severe psychiatric conditions, such as treatment-resistant depression (TRD) and intractable obsessive-compulsive disorder (OCD). Effects of DBS have been reported in similar to 100 cases of OCD and similar to 50 cases of TRD for seven (five common) anatomic targets. Although these published reports differ with respect to study design and methodology, the overall response rate appears to exceed 50% in OCD for some DBS targets. In TRD, >50% of patients responded during acute and long-term bilateral electrical stimulation in a different target. DBS was generally well tolerated in both OCD and TRD, but some unique, target- and stimulation-specific adverse effects were observed (e.g., hypomania). Further research is needed to test the efficacy and safety of DBS in psychiatric disorders, compare targets, and identify predictors of response.

引用

页码：511 / 524

页数：14

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