The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

被引：159

作者：

McKechnie, Julia L. ^{[1
]}

Blish, Catherine A. ^{[1
,2
,3
,4
]}

机构：

[1] Stanford Univ, Sch Med, Program Immunol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[3] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[4] Stanford Univ, Sch Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA

来源：

CELL HOST & MICROBE | 2020年 / 27卷 / 06期

基金：

美国国家科学基金会; 比尔及梅琳达.盖茨基金会;

关键词：

MANNOSE-BINDING LECTIN; CELLS;

D O I：

10.1016/j.chom.2020.05.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.

引用

页码：863 / 869

页数：7

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Bhimraj, Adarsh ;

Morgan, Rebecca L. ;

Shumaker, Amy Hirsch ;

Lavergne, Valery ;

Baden, Lindsey ;

Cheng, Vincent Chi-Chung ;

Edwards, Kathryn M. ;

Gandhi, Rajesh ;

Muller, William J. ;

O'Horo, John C. ;

Shoham, Shmuel ;

Murad, M. Hassan ;

Mustafa, Reem A. ;

Sultan, Shahnaz ;

Falck-Ytter, Yngve .

CLINICAL INFECTIOUS DISEASES, 2020, 78 (07) :e83-e102

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