The Impact of Motivation on Cognitive Performance in an Animal Model of the Negative and Cognitive Symptoms of Schizophrenia

被引:20
|
作者
Ward, Ryan D. [1 ]
Winiger, Vanessa [1 ]
Higa, Kerin K. [1 ]
Kahn, Julia B. [1 ]
Kandel, Eric R. [2 ,3 ]
Balsam, Peter D. [1 ,4 ]
Simpson, Eleanor H. [2 ,5 ]
机构
[1] Columbia Univ, Dept Psychol, New York, NY 10027 USA
[2] Columbia Univ, Dept Neurosci & Psychiat, New York, NY 10027 USA
[3] Howard Hughes Med Inst, Chevy Chase, MD USA
[4] Columbia Univ Barnard Coll, New York, NY 10027 USA
[5] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
基金
美国国家卫生研究院;
关键词
dopamine D2 expression; motivation; attention; schizophrenia; cognition motivation interactions; mouse; NUCLEUS-ACCUMBENS DOPAMINE; D2 RECEPTOR OVEREXPRESSION; WORKING-MEMORY; SUSTAINED ATTENTION; PREFRONTAL CORTEX; CLINICAL-TRIALS; D-2; RECEPTORS; REWARD; OCCUPANCY; DEFICITS;
D O I
10.1037/bne0000051
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Interactions between motivation and cognition are implicated in producing functional impairments and poor quality of life in psychiatric patients. This interaction, however, is not well understood at either the behavioral or neural level. We developed a procedure for mice in which a cognitive measure, sustained attention, is modulated by a motivationally relevant signal that predicts reward probability on a trial-by-trial basis. Using this paradigm, we tested the interaction between motivation and cognition in mice that model the increased striatal D2 receptor activity observed in schizophrenia patients (D2R-OE mice). In control mice, attention was modulated by signaled-reward probability. In D2R-OE mice, however, attention was not modulated by reward-related cues. This impairment was not due to any global deficits in attention or maintenance of the trial-specific information in working memory. Turning off the transgene in D2R-OE mice rescued the motivational modulation of attention. These results indicate that deficits in motivation impair the ability to use reward-related cues to recruit attention and that improving motivation improves functional cognitive performance. These results further suggest that addressing motivational impairments in patients is critical to achieving substantive cognitive and functional gains.
引用
收藏
页码:292 / 299
页数:8
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