Serotonin-2A receptor gene polymorphisms are associated with serotonin-induced platelet aggregation

被引：16

作者：

Shimizu, M

Kanazawa, K

Matsuda, Y

Takai, E

Iwai, C

Miyamoto, Y

Hashimoto, M

Akita, H

Yokoyama, M

机构：

[1] Kobe Univ, Grad Sch Med, Div Gen Med Sci, Dept Gen Therapeut, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Dept Internal Med, Div Cardiovasc & Resp Med, Kobe, Hyogo, Japan

来源：

THROMBOSIS RESEARCH | 2003年 / 112卷 / 03期

关键词：

serotonin; platelet aggregation; polymorphisms; laser-light scattering;

D O I：

10.1016/j.thromres.2003.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serotonin (5HT) induces platelet aggregation through 5HT2A receptor activation. We investigated the relationship between 5HT2A receptor gene polymorphisms and platelet aggregation in 44 healthy volunteers. Small-sized platelet aggregates, induced by 5HT or ADP, were evaluated with a novel laser-light scattering method. T102C polymorphism and -1438A/G polymorphism of 5HT2A receptor gene is associated with 5HT-induced small-sized platelet aggregation, suggesting that these polymorphisms have functional significance.

引用

收藏

页码：137 / 142

页数：6

相关论文

共 25 条

[1] ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE [J].

ARRANZ, M ;

COLLIER, D ;

SODHI, M ;

BALL, D ;

ROBERTS, G ;

PRICE, J ;

SHAM, P ;

KERWIN, R .

LANCET, 1995, 346 (8970) :281-282

[2] Association between 5-HT2A gene promoter polymorphism and anorexia nervosa [J].

Collier, DA ;

Arranz, MJ ;

Li, T ;

Mupita, D ;

Brown, N ;

Treasure, J .

LANCET, 1997, 350 (9075) :412-412

[3] Platelet aggregation in acute coronary syndromes: use of a new aggregometer with laser light scattering to assess platelet aggregability [J].

Eto, K ;

Takeshita, S ;

Ochiai, M ;

Ozaki, Y ;

Sato, T ;

Isshiki, T .

CARDIOVASCULAR RESEARCH, 1998, 40 (01) :223-229

[4]

KITEK A, 1980, THROMB HAEMOSTASIS, V44, P154

[5] Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects:: a negative study [J].

Kusumi, I ;

Suzuki, K ;

Sasaki, Y ;

Kameda, K ;

Sasaki, T ;

Koyama, T .

JOURNAL OF AFFECTIVE DISORDERS, 2002, 68 (2-3) :235-241

[6] Platelet GP IIIa PlA polymorphisms display different sensitivities to agonists [J].

Michelson, AD ;

Furman, MI ;

Goldschmidt-Clermont, P ;

Mascelli, MA ;

Hendrix, C ;

Coleman, L ;

Hamlington, J ;

Barnard, MR ;

Kickler, T ;

Christie, DJ ;

Kundu, S ;

Bray, PF .

CIRCULATION, 2000, 101 (09) :1013-1018

[7] 5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa [J].

Nacmias, B ;

Ricca, V ;

Tedde, A ;

Mezzani, B ;

Rotella, CM ;

Sorbi, S .

NEUROSCIENCE LETTERS, 1999, 277 (02) :134-136

[8] A novel role for serotonin in heart [J].

Nebigil, CG ;

Maroteaux, L .

TRENDS IN CARDIOVASCULAR MEDICINE, 2001, 11 (08) :329-335

[9] Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients [J].

Nishiguchi, N ;

Matsushita, S ;

Suzuki, K ;

Murayama, M ;

Shirakawa, O ;

Higuchi, S .

BIOLOGICAL PSYCHIATRY, 2001, 50 (02) :123-128

[10] Two naturally occurring amino acid substitutions of the 5-HT2A receptor: Similar prevalence in patients with seasonal affective disorder and controls [J].

Ozaki, N ;

Rosenthal, NE ;

Pesonen, U ;

Lappalainen, J ;

FeldmanNaim, S ;

Schwartz, PJ ;

Turner, EH ;

Goldman, D .

BIOLOGICAL PSYCHIATRY, 1996, 40 (12) :1267-1272