Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering

被引：40

作者：

Becker, Judith ^{[1
]}

Giesselmann, Gideon ^{[1
]}

Hoffmann, Sarah Lisa ^{[1
]}

Wittmann, Christoph ^{[1
]}

机构：

[1] Saarland Univ, Inst Syst Biotechnol, D-66123 Saarbrucken, Germany

来源：

SYNTHETIC BIOLOGY - METABOLIC ENGINEERING | 2018年 / 162卷

关键词：

Diaminopentane; Industrial biotechnology; Industrial raw material; Lysine; Metabolic network; Pathway engineering; Rational design; L-LYSINE PRODUCTION; OXYGEN-DEPRIVATION CONDITIONS; SUCCINIC ACID PRODUCTION; PENTOSE-PHOSPHATE PATHWAY; L-VALINE PRODUCTION; TRANSCRIPTIONAL REGULATORY NETWORKS; EFFICIENT ISOBUTANOL PRODUCTION; ADAPTIVE LABORATORY EVOLUTION; CARBON-FLUX DISTRIBUTION; GAMMA-AMINOBUTYRIC-ACID;

D O I：

10.1007/10_2016_21

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its discovery 60 years ago, Corynebacterium glutamicum has evolved into a workhorse for industrial biotechnology. Traditionally well known for its remarkable capacity to produce amino acids, this Gram-positive soil bacterium, has become a flexible, efficient production platform for various bulk and fine chemicals, materials, and biofuels. The central turnstile of all these achievements is our excellent understanding of its metabolism and physiology. This knowledge base, together with innovative systems metabolic engineering concepts, which integrate systems and synthetic biology into strain engineering, has upgraded C. glutamicum into one of the most successful industrial microorganisms in the world.

引用

页码：217 / 263

页数：47

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