Role of the Lipid Peroxidation in the Assessment of the Consequences of Exposure to Chemical Toxicants on Bio-Objects

The effect of chemical toxicants from different groups (surfactant, acetone, sodium thiophosphate, waste of pulp, and paper production) is studied on the state of lipid peroxidation (LPO) processes in the model system (spontaneous low-temperature oxidation of lecithin in a polar medium) and on injection into the organism of laboratory mice. Analysis of the state of the oxidative processes in the model system and in the liver of mice showed that, in systems of varying complexity, chemical toxicants affect the state of the lipid component of membranes depending on the initial intensity of LPO. The effect of toxicants on biological objects causes disturbances in the regulation of lipid peroxidation, regardless of their nature and way of entering the organism and is the main reason for their toxicity.