Anti-NMDA receptor encephalitis presenting as isolated aphasia in an adult

被引：10

作者：

Constantinides, Vasilios C. ^{[1
]}

Kasselimis, Dimitrios S. ^{[1
,2
]}

Paraskevas, George P. ^{[1
]}

Zacharopoulou, Maria ^{[1
]}

Andreadou, Elisabeth ^{[1
]}

Evangelopoulos, Maria-Eleftheria ^{[1
]}

Kapaki, Elisabeth ^{[1
]}

Kilidireas, Costas ^{[1
]}

Stamboulis, Eleftherios ^{[1
]}

Potagas, Constantin ^{[1
]}

机构：

[1] Univ Athens, Eginit Hosp, Dept Neurol 1, Athens, Greece

[2] Univ Crete, Sch Med, Dept Psychiat, Iraklion, Greece

来源：

NEUROCASE | 2018年 / 24卷 / 04期

关键词：

Anti-NMDA-r encephalitis; aphasia; immunotherapy; language; cognitive decline; NONCONVULSIVE STATUS EPILEPTICUS; ANTIBODIES ENCEPHALITIS; AUTOIMMUNE ENCEPHALITIS; VOCABULARY MEASURES; OVARIAN TERATOMA; ACUTE-PSYCHOSIS; DIAGNOSIS; GREEK; MIMICKING; CHILDREN;

D O I：

10.1080/13554794.2018.1524915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-NMDA receptor (NMDA-r) encephalitis is a relatively rare cause of autoimmune encephalitis with divergent clinical presentations. We report a case of an adult patient with anti-NMDA-r encephalitis presenting with isolated, abrupt-onset aphasia. Her condition remained unaltered over a period of 6months. The patients' electroencephalogram findings were typical for NMDA-r encephalitis; however, her magnetic resonance imaging and cerebrospinal fluid analysis were normal. She responded well to immunotherapy, and aphasia eventually resolved. The natural course of the present case contradicts the rapidly progressive nature of typical NMDA-r encephalitis. Furthermore, it broadens the clinical spectrum of anti-NMDA-r encephalitis, to incorporate isolated, nonprogressive aphasia.

引用

页码：188 / 194

页数：7

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